Five touchdown passes by Drew Brees and three turnovers by the Buffalo Bills - that's pretty much the story of the Bills 35-17 loss in New Orleans.

It wasn't the Bills day from the beginning when Thad Lewis fumbled on the first play from scrimmage and appeared to be seriously injured. The Bills defense held, Lewis returned, and for a while it looked like an upset in the making when the Bills took a 10-7 lead, but Brees was just too much for the Bills defense.

Brees finished with 332 yards passing and the five touchdowns, including a 69-yard hookup with Kenny Stills in the second quarter that gave the Saints the lead for good.

It was a tough day for Bills quarterback Thad Lewis, who connected on a 13-yard touchdown to Stevie Johnson in the second quarter to tie the game, but Lewis turned the ball over three times on a pair of fumbles and an interception.

The Bills drop to 3-5 at the halfway point of the season. They host the undefeated Kansas City Chiefs next Sunday at Wilson Stadium.