The Buffalo Bills are favored to beat the Pittsburgh Steelers on Sunday at Highmark Stadium. The 14.5-spread in Buffalo's favor is the largest point spread underdog the Steelers have ever been.

Pittsburgh will also be starting a rookie quarterback, Kenny Pickett, which will be his first career NFL start.

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However, the Bills are dealing with quite a few injuries and have been since the conclusion of their week 2 home opener against the Tennessee Titans.

The Bills have lost safety Micah Hyde and tackle Tommy Doyle for the rest of the season, while Tre'Davious White is still on PUP, recovering from ACL surgery.

On Friday, head coach Sean McDermottt confirmed on WGR radio that a few other players will miss Sunday's game against the Steelers.

Both safety Jordan Poyer and tight end Dawson Knox are declared out for Sunday's game.

Cornerback Christian Benford is still recovering from his broken hand and Jamison Crowder broke his ankle against the Baltimore Ravens last Sunday. They also were declared out, as was wide receiver Jake Kumerow with his high ankle sprain.

Isaiah McKenzie remains in concussion protocol.

The Steelers are also going through injuries as well, as star edge rusher T.J. Watt will miss Sunday's game and other defensive stars like Minkah Fitzpatrick and Cameron Heyward were limited in Thursday's practice.

Poyer out means that Damar Hamlin and Jaquan Johnson will start at safety, while Quintin Morris and Tommy Sweeney will split snaps in place of Knox.

This game won't be a cakewalk but considering the following week is at the Kansas City Chiefs, it makes it more important for the long run that the Bills have these guys healthy.

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